Anti-Presenilin 1 Monoclonal Antibody

Product Name

Anti-Presenilin 1 Monoclonal Antibody

View all Presenilin-1 Antibodies

SKU/Catalog Number

M00138-1

Size

100 μl

Form

Liquid

Description

Boster Bio Anti-Presenilin 1 Monoclonal Antibody catalog # M00138-1. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Presenilin 1 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00138-1)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Clonality

Monoclonal

Clone Number

AECD-16

Isotype

Rabbit IgG

Immunogen

A synthesized peptide derived from human Presenilin 1 Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) . Requires the other members of the gamma-secretase complex to have a protease activity.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00138-1 is reactive to PSEN1 in Human, Mouse, Rat

Applications

M00138-1 is guaranteed for Flow Cytometry, WB Boster Guarantee

Observed Molecular Weight

25 kDa

Calculated molecular weight

52.668kDa

Background of Presenilin-1

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns (4,5) P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) . PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-1:2000
FC 1:10

Validation Images & Assay Conditions

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Western blot analysis of Presenilin 1 expression in Jurkat cell lysate.

Gene/Protein Information For PSEN1 (Source: Uniprot.org, NCBI)

Alternative Names

AD3EC 3.4.23.-; Alzheimer disease 3; EC 3.4.23; FAD; presenilin 1; Presenilin1; Presenilin-1; Protein S182; PS-1; PS1presenilin-1; PSEN1; PSNL1; S182 PSEN1 ACNINV3, AD3, FAD, PS-1, PS1, S182 presenilin 1 presenilin-1

For more info on PSEN1, check out the PSEN1 Infographic

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In this infographic, you will see the following information for PSEN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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